Amorolfine hydrochloride ( Ro 14-4767/002 )

Catalog No. M15962 CAS No. 78613-38-4

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Product Name

Amorolfine hydrochloride
Note

Research use only, not for human use.
Brief Description

Amorolfine Hydrochloride is an antifungal reagent.
Description

Amorolfine Hydrochloride is an antifungal reagent. It exerts the antifungal activity by selectively blocking two steps in the pathway of ergosterol synthesis, and eventually damaging the structure and function of fungal cell membrane. Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.
Synonyms

Ro 14-4767/002
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Infection
Indication

——

CAS Number

78613-38-4
Formula Weight

353.97
Molecular Formula

C21H36ClNO
Purity

>98%(HPLC)
Solubility

Ethanol: 71 mg/mL (200.58 mM); Water: 9 mg/mL (25.42 mM); DMSO: 28 mg/mL (79.1 mM)
SMILES

CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2C[C@H](O[C@H](C2)C)C.Cl
Chemical Name

——

1.Espinel-Ingroff A, et al. Antimicrob Agents ChemOthers. 1984 Jul; 26(1):5-9.

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